Kita or Minami
Osaka is organised around two hubs about three kilometres apart, and locals talk about the city that way. Kita — north — is Umeda and Osaka Station. Minami — south — is Namba, Shinsaibashi and Dotonbori. Almost every visitor should stay in one of them.
Kita is the transport city. Osaka Station and Umeda's private-railway terminals put Kyoto, Kobe, Nara, Himeji and both airports within easy reach, and the area is a dense block of department stores, food halls and office towers.
Minami is the eating city. Dotonbori, Kuromon Market, the Ura-Namba lanes, the arcades — this is the Osaka people come for, and it is at its best from six in the evening onwards.
The subway connects them in about ten minutes, so neither choice cuts you off from the other. The question is only which one you want to walk out of your hotel into.
The short recommendation: Namba or Shinsaibashi if this is your first visit and you are here for the food and the atmosphere. Umeda if you are using Osaka as a base for Kyoto, Nara and Kobe day trips, or if you have an early flight.
One useful fact: Osaka hotels are consistently cheaper and larger than Kyoto's, and the city is 15 to 30 minutes from Kyoto by train. A lot of travellers should be sleeping here and commuting the other way.

Ura-Namba Bar Crawl
Three hours in the counters behind the neon, with a guide who can order for you.
From $46
3 hours
